The HRPP has developed the following resources to assist researchers with navigating the Cayuse platform and the new IRB application:

Cayuse Human Ethics Training Videos


1. Cayuse HE Login and Platform
2. Starting New Initial Application and Key Points
3. Completing and Submitting the New Initial Application

Screenshots for submissions

  • New initial applications 

  • Modification requests

    • Expedited and Full board studies approved in iRIS are in the process of being migrated into Cayuse HE. Modifications for those studies cannot be submitted until your study has been migrated and the HRPP has notified you via email. If you need to submit a modification and you have not been informed that your study has been migrated, please email us at, so that we can prioritize the migration of your study.
  • Reportable events 

  • Closure form 

Cayuse Tech Help

The HRPP can assist researchers with navigating Cayuse HE upon request. Please email us at to set up a quick appointment via Teams or Zoom to answer your Cayuse HE questions.

  • Advising appointments are also available upon request for advising on study materials and documents, as well as extended technical assistance using Cayuse HE


The HRPP FAQ page contains extensive information and guidance on many commonly asked topics.