Collaborative Program Grant for Multidisciplinary Teams (RM1)

This funding opportunity is designed to support highly integrated research teams of three to six PD/PIs to address ambitious and challenging research questions that are important for the mission of NIGMS and are beyond the scope of one or two investigators. Collaborative program teams are expected to accomplish goals that require considerable synergy and managed team interactions. Project goals should not be achievable with a collection of individual efforts or projects. Teams are encouraged to consider far-reaching objectives that will produce major advances in their fields. This opportunity encourages Collaborative Program Grant applications from institutions/organizations that propose to conduct research to address complex and challenging biomedical problems, through deeply integrated, multidisciplinary research teams. The Collaborative Program Grant is designed to support research in which funding a team of interdependent investigators offers significant advantages over support of individual research project grants. Applications should address critical issues and be sufficiently challenging, ambitious, and innovative that objectives could not be achieved by individual investigators.

Application Due Date(s) - for the Agency Due Date of January 25, 2020.

  • Research Office Internal Letter of Intent Due Date: Monday, September 30, 2019 by 5 pm PST.  Email to
  • Agency Letter of Intent Due Date: December 25, 2020.
  • Agency full proposal Due Date:  January 25, 2020.


Application Due Date(s) - for the Agency Due Date of May 25, 2020

  • Research Office Internal Letter of Intent Due Date: Friday, February 28, 2020 by 5 pm PST.  Email to
  • Agency Letter of Intent Due Date: April 25, 2020.
  • Agency full proposal Due Date:  May 25, 2020


By 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on these dates.

  • Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date
  • NIGMS anticipates supporting no more than 4-6 awards, corresponding to a total of $10,000,000 (total costs), for fiscal year 2019. Future year amounts will depend on annual appropriations and Institute priorities.
  • Only one application per institution per review cycle is allowed, as defined in Section III. 3. Additional Information on Eligibility.  - Interested - please email

Letter of Intent Guidelines:

COVER SHEET (1 page)

  • Solicitation Name and Descriptive Title
  • Project Summary: 3 or 4 sentences or bullet points that provide an overview of the objective of your proposed research, how you plan to do it, and the expected outcome.
  • Unique Aspects: 3 or 4 sentences or bullet points that highlight how your research/approach is different/better.
  • Key PI/co-PIs: 5 or 6 sentences or bullet points that highlight team expertise as it relates to the project.
  • Budget: Example: The total cost of the project is anticipated to be $ X, with $ Y being requested from the NIH. NIH funds will be used for: $ A for personnel; $ B for operations, and $ C for broader impacts/subcontracts etc.
  • Justification for NIH support: One paragraph explaining why this research fits with the RFP and strategic goals of NIH.


  • Problem statement - Clear and concise statement of 1) research question(s) and how the project will address the research question(s); 2) what technical barriers need to be overcome to perform the research; and 3) how the proposed research can lead to the advancement of research/knowledge in this area.
  • Conceptual framework: Conceptual framework describing, for example, how the synthesis of various project components, approaches, and participant expertise are linked together to address the problem of interest. Graphics may be used.
  • Proposed activities: Describe the project to be undertaken and provide the technical specifications of the research activities and timelines that will be undertaken.
  • Expected results: Describe the outcome you anticipate from the research. (Remember your initial motivation for wanting to do this!)
  • Peer Groups: Who else is doing something similar, why their discoveries are useful for you, and what discriminates you.
  • Broader Impact/Metrics for Success: What metrics are the most appropriate for evaluating the success of the proposed project (e.g., peer-reviewed papers, policy-directed efforts, databases, models, development of new resources, etc.)? If successful, who would most likely use the knowledge or tools developed?
  • Fundraising: List any matching fund requests, industry commitments etc. List any similar current proposals pending.




Monday, September 30, 2019
Date Open: 
Thursday, September 28, 2017
Agency Deadline: 
Saturday, January 25, 2020
Limit per Institution: 
1 application per cycle
Important Notes: 
Note the two cycles/ Jan 25, 2020 and May 25, 2020