If I am collaborating...
The application form is designed to assist the OSU HRPP in identifying which activities in a multi-center study will be conducted by OSU researchers. Researchers should complete the relevant sections of the application (see the Submission Steps under New Applications).
External Collaborators and IRBs
All investigators conducting human subjects research must be covered by an IRB approval or exempt determination regardless of their affiliation with OSU. To determine which investigators should be listed on the OSU application, you can contact the HRPP Office at [email protected].
There is a mechanism in place for one IRB to rely on another for non-exempt research*. This reduces the need for multiple IRBs to review a single study. Most IRBs, but not all, are willing to use a reliance process. Therefore, there are three options for ensuring that investigators from multiple institutions are covered by an IRB approval for a single study:
- The OSU IRB can rely on an external institution's IRB review. Please see the investigator responsibilities for this option.
- The OSU IRB can review the study and the external institution can rely on the OSU IRB's review. Please see the investigator responsibilities for this option.
- Each institution's IRB can oversee the research separately (except for non-exempt, NIH-funded research)
HRPP staff will help OSU researchers navigate these decisions by speaking directly with the external IRB(s). If there are external collaborators, please provide appropriate contact information for the collaborating institution's IRB in the application.
The OSU HRPP is also a member of the SMART IRB reliance system. If you are collaborating with researchers at another SMART IRB member institution, you may need to provide information through the SMART IRB Platform as well. The HRPP office will provide additional instructions during the review process.
*If a study is determined to be exempt by either the OSU HRPP or by the external institution, OSU will not enter into a reliance agreement for the project. In this case, the principal investigator at each institution will need to submit an application to their own IRB for an exempt determination.
The OHSU and OSU IRBs have a Memorandum of Understanding (MOU) that enables OSU to rely on OHSU under the following circumstances:
- Research that recruits and enrolls only OHSU research subjects, or
- Research that is conducted by faculty with joint OHSU/OSU appointments, or
- Applications for which OHSU is either the primary or sub-awardee on a grant or contract, so long as OHSU is considered engaged in research as defined by the Office of Human Research Protections (OHRP).
To request that the OSU IRB rely on the OHSU IRB, the OSU PI will submit an initial application in Cayuse HE, and indicate in the "External Collaboration" section that OSU will rely on the OHSU IRB, and attach the protocol and approval documents from the OHSU IRB.
After OSU cedes oversight, it is the PI’s responsibility to ensure that OSU receives updated copies of approvals and approved documents from OHSU.